In addition to the natural, wholefood sources - Vitamin B6 can be found in serums, shampoos, conditioners, vitamin B complex supplements and multivitamins. It is also added to fortified foods like bread and breakfast cereals.

Pyridoxine is it typically appears in fortified foods, supplements, and cosmetic products is made using a multistage process where the primary reagents 4-Methyl-5-ethyl oxazole and n-Propyl dioxepin are added together in ethanol and hydrochloric acid bath. Activated charcoal is then added to absorb any unwanted impurities. The resulting vitamin B6 is then crystalised and made ready for use by nutritional supplement, food and cosmetic companies.

The fortification of maize and bread flour with vitamin B6 is compulsory in South Africa.

Vitamin B6 is said to be able to treat various skin conditions and regular sebum production, however there is not scientific evidence to prove that.